In this study, we show that 6S-1 RNA from *Bacillus subtilis" produces a short transcript called "pRNA". This pRNA has the potential to hybridise with its template and that this induces a conformational change in the 6S-1 RNA structure.
Since off-target effects in non-viral siRNA delivery are quite common but not well understood, in this study various polymer-related effects observed in transfection studies were described and their mechanisms of toxicity were investigated. A variety …
Evolutionary conserved mitochondrial nucleases are involved in programmed cell death and normal cell proliferation in lower and higher eukaryotes. The endo/exonuclease Nuc1p, also termed 'yeast Endonuclease G (EndoG)', is a member of this class of …